Technology has the potential to break our reliance on annual or seasonal vaccinations and provide longer durability and greater reliability for coronaviruses, influenza, rhinoviruses, and more. Through innovation, there is an opportunity to increase the impact and acceptance of vaccinations and develop more consistent and impactful outcomes to reach large numbers of individuals, regardless of risk level, with one or more vaccines and limit the spread of infection disease. This program will address the state of breaking the seasonal dependencies and what challenges lie ahead for researchers and innovators.